Simulated Microgravity Conditions Modulate Ca 2+ Transport through TRPV4 Channels
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چکیده
منابع مشابه
Simulated microgravity alters rat mesenteric artery vasoconstrictor dynamics through an intracellular Ca(2+) release mechanism.
Previous work has shown that orthostatic hypotension associated with cardiovascular deconditioning results from inadequate peripheral vasoconstriction. We used the hindlimb-unloaded (HU) rat in this study as a model to induce cardiovascular deconditioning. The purpose of this study was to test the hypothesis that 14 days of HU diminishes vasoconstrictor responsiveness of mesenteric resistance a...
متن کاملFunctional alterations in cerebrovascular K and Ca channels are comparable between simulated microgravity rat and SHR
Xie, Man-Jiang, Li-Fan Zhang, Jin Ma, and Hong-Wei Cheng. Functional alterations in cerebrovascular K and Ca channels are comparable between simulated microgravity rat and SHR. Am J Physiol Heart Circ Physiol 289: H1265–H1276, 2005. First published May 13, 2005; doi:10.1152/ajpheart.00074.2005.—Exposure to microgravity leads to a sustained elevation in transmural pressure across the cerebral va...
متن کاملFunctional alterations in cerebrovascular K(+) and Ca(2+) channels are comparable between simulated microgravity rat and SHR.
Exposure to microgravity leads to a sustained elevation in transmural pressure across the cerebral vasculature due to removal of hydrostatic pressure gradients. We hypothesized that ion channel remodeling in cerebral vascular smooth muscle cells (VSMCs) similar to that associated with hypertension may occur and play a role in upward autoregulation of cerebral vessels during microgravity. Spragu...
متن کاملSimulated microgravity alters rat mesenteric artery vasoconstrictor dynamics through an intracellular Ca release mechanism
Patrick N. Colleran, Bradley J. Behnke, M. Keith Wilkerson, Anthony J. Donato, and Michael D. Delp Department of Health and Kinesiology, Texas A&M University, College Station, Texas; Division of Exercise Physiology and the Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, West Virginia; and Department of Applied Physiology...
متن کاملSmall conductance Ca 2 + - activated K + channels modulate 2 action potential - induced Ca 2 + transients in hippocampal neurons . 3 4
4 Raffaella Tonini, Teresa Ferraro, Marisol Sampedro-Castañeda, Anna Cavaccini, Martin 5 Stocker, Christopher D. Richards and Paola Pedarzani* 6 7 Research Department of Neuroscience, Physiology and Pharmacology, University College London, 8 London, UK. 9 Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy. 10 11 *To whom correspondence should be ad...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.11.1371